Hi, I am Elmar Hubrich and have studied physics in Karlsruhe and Berlin (TU). I am a PhD student in the group of Prof. Dr. Heberle.
I am using tip-enhanced Raman spectroscopy (TERS), which combines high spatial resolution of atomic force microscopy (AFM) with structural sensitivity of surface-enhanced Raman spectroscopy (SERS). Using a gold-coated AFM tip, it is possible to measure Raman with a spatial resolution up to 30 nm.
The AFM allows imaging, measuring (e.g.: single-molecule force spectroscopy), and manipulating matter at the nanoscale. The information is gathered by "feeling" the surface with a mechanical probe.
Raman spectroscopy provides structural information of proteins on the atomic/molecular level. In order to detect a Raman signal of a protein monolayer, we exploit the increased light sensitivity of surface-enhanced Raman scattering (SERS). The SERS signal is enhanced in the vicinity of silver- or gold-coated surfaces.
My goal is to use TERS for measuring Raman signals of proteins in or on a biomembrane.