Pulses, Channels and Single Molecules at Interfaces and the Physics of Blood Clotting

Sep 24, 2012 | 02:00 PM

Location

Prof. Matthias F. Schneider, Biological Physics Group, Boston University, Boston, USA

Two main motivations will drive my presentation:i) How can the physical properties of interfaces help to understand biology and ii) How can physics explain the counterintuitive observation of increasing adhesion with rising shear stress?I will briefly outline the idea of Einstein’s reversion and demonstrate that applied to the soft interface it predicts the existence of ion channels in any interface. The theory is confirmed in BLM experiments. Further the existence of propagating waves in lipid membranes is predicted and confirmed in experiments on lipid monolayers. Finally, we apt to bridge the gap between physics and biochemistry and demonstrate that the activity of enzymes is controlled by interface thermodynamics and that mechanical models fail to explain our experiments.We conclude by proposing a new mechanism for biological signaling, which predicts the communication between single molecules and the propagation along nerve fibers.In the second part of my presentation an acoustically driven microfluidic device is presented and applied to study hydrodynamic stress activated blood clotting from single molecules to the collective formation ofreversible blood clots under dynamic conditions.

Time & Location

Sep 24, 2012 | 02:00 PM

Lecture Hall, 1.3.14