1990 - 2000

von Bergen, M., Friedhoff, P., Biernat, J., Heberle, J., Mandelkow, E.-M., Mandelkow, E.
´Assembly of t protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming beta structure`,
Proc. Natl. Acad. Sci. USA 97, 5129-5134

Heberle, J. *,
´Proton Transfer Reactions Across Bacteriorhodopsin and Along the Membrane`,
Biochim. Biophys. Acta 1458, 135-147

Heberle, J., Fitter, J., Sass, H.J. & Büldt, G. *,
´Bacteriorhodopsin: The functional details of a molecular machine are being resolved´,
Biophys. Chem. 85, 229-248

Fitter, J. & Heberle, J.,
´Structural equilibrium fluctuations and thermal stability of mesophilic and thermophilic a-amylase´,
Biophys. J. 79, 1629-1636

Zscherp, C., Schlesinger, R., Tittor, J., Oesterhelt, D., & Heberle, J.,
´In-situ Determination of Transient pKa Changes of Internal Amino Acids of Bacteriorhodopsin using Time-Resolved Attenuated Total Reflection Fourier-Transform Infrared Spectroscopy ´,
Proc. Natl. Acad. Sci. USA 96, 5498-5503

Büldt, G., Heberle, J., Schlesinger, R. & Sass, H.J. *,
´Structure, dynamics, and function of the proton pump bacteriorhodopsin´,
in: Methods in Protein Structure Analysis (Ed. Roza, Maria Kamp), Springer Verlag, Berlin, pp. 225-239

Heberle, J. *,
`Time-resolved ATR/FT-IR spectroscopy of Membrane Proteins`,
Recent Research Developments in Applied Spectroscopy (S. G. Pandalai, ed.), Research Signpost, Trivandrum, pp. 147-159

Heberle, J., Büldt, G., Koglin, E., Rosenbusch, J. P., & Landau, E. M.,
´Assessing the Functionality of a Membrane Protein in a Three-Dimensional Crystal´,
J. Mol. Biol. 281, 587-592

Büldt, G., Heberle, J., Dencher, N.A. & Sass, H.J.,
´Structure, dynamics, and function of bacteriorhodopsin´,
J. Protein Chem. 17, 536-538

Zscherp, C., & Heberle, J.,
´Infrared difference spectra of the intermediates L, M, N, and O of the Bacteriorhodopsin photoreaction obtained by time-resolved attenuated total reflection spectroscopy´,
J. Phys. Chem. 101, 10542-10547

Heberle, J., & Zscherp, C.,
´pH-dependence of proton transfer reactions within Bacteriorhodopsin: A time-resolved ATR/FT-IR study´,
in: Spectroscopy of Biological Molecules, Modern Techniques (Ed. P. Carmona, et al.), Kluwer Academic Publishers, Dordrecht, Niederlande, pp. 117-118

Riesle, J., Oesterhelt, D., Dencher, N.A. & Heberle, J.,
´D38 is an essential part of the proton translocation pathway in Bacteriorhodopsin´,
Biochemistry 35, 6635-6643

Heberle, J., & Zscherp, C.,
´ATR/FT-IR difference spectroscopy of biological matter with microsecond time resolution´,
Appl. Spectrosc. 50, 588-596

Zscherp, C., Büldt, G., & Heberle, J.,
´Time-resolved ATR/FT-IR measurements of the Bacteriorhodopsin photocycle´, in: Spectroscopy of Biological Molecules (Ed. J.C. Merlin, et al.), Kluwer Academic Publishers, Dordrecht, Niederlande, pp. 177-178

Hoffmann, A., Hildebrandt, V., Heberle, J. & Büldt, G.,
´Photoactive mitochondria: In vivo transfer of a light-driven proton pump into the inner mitochondrial membrane of Schizosaccharomyces pombe´,
Proc. Natl. Acad. Sci. USA 91, 9367-9371

Heberle, J., Riesle, J., Thiedemann, G., Oesterhelt, D. & Dencher, N.A.,
´Proton migration along the membrane surface and retarded surface to bulk transfer´,
Nature 370, 379-382

Heberle, J., Oesterhelt, D. & Dencher, N.A.,
´Decoupling of photo- and proton cycle in the Asp85Glu mutant of Bacteriorhodopsin´,
EMBO J. 12, 3721-3727

Hildebrandt, V., Fendler, K., Heberle, J., Hoffmann, A., Bamberg, E. & Büldt, G.,
´Bacteriorhodopsin expressed in Schizosaccharomyces pombe pumps protons through the plasma membrane´,
Proc. Natl. Acad. Sci. USA 90, 3578-3582

Heberle, J. & Dencher, N.A.,
´Surface-bound optical probes monitor proton translocation and surface potential changes during the Bacteriorhodopsin photocycle´,
Proc. Natl. Acad. Sci. USA 89, 5996-6000

Heberle, J. & Dencher, N.A.,
´Proton transfer in the light-harvesting membrane protein bacteriorhodopsin - An investigation with optical pH-indicators´,
in: Proton Transfer in Hydrogen-Bonded Systems (Ed. T. Bountis), NATO ASI Series B Physics, Vol. 291, Plenum Press, New York, pp. 187-197

Heberle J. & Dencher, N.A.,
´The surface of the purple membrane: A transient pool for protons ?´,
in: Structures and Functions of Retinal Proteins (Ed. J.L. Rigaud), Colloque INSERM/John Libbey Eurotext Ltd., Vol. 221, pp. 221-224

Dencher, N.A., Büldt, G., Heberle, J., Höltje, H.-D. & Höltje, M.,
´Light-triggered opening and closing of an hydrophobic gate controls vectorial proton transfer across Bacteriorhodopsin´,
in: Proton Transfer in Hydrogen-Bonded Systems (Ed. T. Bountis), NATO ASI Series B Physics, Vol. 291, Plenum Press, New York, pp. 171-185

Dencher, N.A., Heberle, J., Büldt, G., Höltje, H.-D. & Höltje, M.,
´What do neutrons, X-ray synchrotron radiation, optical pH-indicators, and mutagenesis tell us about the light-driven proton pump Bacteriorhodopsin ?´,
in: Membrane Proteins: Structures, Interactions and Models (Eds. Pullmann et al.), Kluwer Academic Publishers, Dordrecht, Niederlande, pp. 69-84

Dencher, N.A., Heberle, J., Büldt, G., Höltje, H.-D. & Höltje, M.,
´Active and passive proton transfer steps through Bacteriorhodopsin are controlled by a light-triggered hydrophobic gate´,
in: Structures and Functions of Retinal Proteins (Ed. J.L. Rigaud), Colloque INSERM/John Libbey Eurotext Ltd.Vol. 221, pp. 213-216

Thiedemann, G., Heberle, J. & Dencher, N.A.,
´Bacteriorhodopsin pump activity at reduced humidity´,
in: Structures and Functions of Retinal Proteins (Ed. J.L. Rigaud), Colloque INSERM/John Libbey Eurotext Ltd., Vol. 221, pp. 217-220

Dencher, N.A., Heberle, J., Bark, C., Koch, M.H.J., Rapp, G., Oesterhelt, D., Bartels, K. & Büldt, G.,
´Proton translocation and conformational changes during the Bacteriorhodopsin photocycle: Time-resolved studies with membrane-bound optical probes and X-ray diffraction´,
Photochem. Photobiol. 54, 881-887

Heberle, J. & Dencher, N.A. (1990),
´Bacteriorhodopsin in ice - Accelerated proton transfer from the purple membrane surface´,
FEBS Lett. 277, 277-280