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Fast protein folding is governed by memory-dependent friction

In this paper, we evaluate the time-dependent friction kernels for the folding dynamics of eight fast-folding proteins and show that friction relaxation times are long, comparable to protein folding times. By applying memory-kernel extraction techniques to the dynamics of well-characterized reaction coordinates, we directly access the folding friction, which is typically otherwise evaluated by fitting some reaction kinetic model. As such, we parameterize a range of reaction kinetic models and show that models explicitly accounting for non-Markovian effects are the most accurate for predicting the population of protein folding rates.

News from Oct 15, 2024

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