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M.Sc. Pit Langner

Hello, my name is Pit Langner. After finishing my Master’s Thesis I rejoined the AG Heberle in 2017 for my PhD. Currently, I am in charge of maintaining and augmenting the infrared spectrometer setup developed by Bernd-Joachim Schulz, which is based on tunable quantum cascade lasers as probing light source and provides the means to perform time-resolved experiments on proteins in aqueous solution. For my research I am focused on resolving the protonation dynamics within Cytochrome c Oxidase during its catalytic cycle.

foto_pit

Department of Physics

Institute of Experimental Physics

Experimental Molecular Biophysics

PhD Candidate

Address
Arnimallee 14
Room 1.1.36
14195 Berlin
Email
pit.langner (at) fu-berlin.de

Pit Langner born 1990 in Berlin, Germany

Bachelor of Science 2012, Freie Universiät Berlin

Master of Science 2015, Freie Universität Berlin

Previously I investigated proteins carrying a light-oxygen-voltage (LOV) domain for blue-light sensing via steady-state Fourier transform infrared (FTIR) and UV/Vis spectroscopy in conjunction with site-directed mutagenesis, H/D and H216O/H218O exchange and Stark labeling. Although obviously still in the field of biophysics, my research interest shifted when I started my PhD. Now I am utilizing the capabilities of the tunable QCL setup in combination with microfluidics and a flow-flash approach to primarily study (in close cooperation with Federico Baserga) the terminal enzyme of the respiratory chain, Cytochrome c Oxidase (CcO).

Schubert L, Langner P, Ehrenberg D, Lorenz-Fonfria VA, Heberle J
Protein conformational changes and protonation dynamics probed by a single shot using quantum-cascade-laser-based IR spectroscopy
J Chem Phys. 2022 May 28;156(20):204201,  doi: 10.1063/5.0088526

Kerruth S, Langner P, Raffelberg S, Gärtner W, Heberle, J
Characterization of the blue-light activated adenylyl cyclase mPAC by flash photolysis and FTIR spectroscopy
Photochem. Photobiol. (2017) 93, 637–907; 10.1111/php.12746