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DFG project approved for AG Kozuch - Influence of electrostatics on protein misfolding at membranes in neurodegenerative diseases

Based on a DFG-funded project, the Kozuch working group will investigate the influence of the lipid membrane - in particular its electrostatic properties - on the misfolding of proteins in neurodegenerative diseases. Methodologically, we will use surface-enhanced (SEIRA) and nano-infrared spectroscopy (based on atomic force microscopy) in combination with membrane model systems. Interested candidates for a doctoral thesis within this project can contact Dr. Contact Jacek Kozuch ( jacek.kozuch@fu-berlin.de ). Call for applications: https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/wiss/20_fb-physik/PH-KO5464-5.html

Apr 29, 2022

Science paper on NmHR has been released

Chloride transport by microbial rhodopsins is an essential process for which molecular details—such as the mechanisms that convert light energy to drive ion pumping and ensure the unidirectionality of the transport—have remained elusive. We combined time-resolved serial crystallography with time-resolved spectroscopy and multiscale simulations to elucidate the molecular mechanism of a chloride pumping rhodopsin and the structural dynamics throughout the transport cycle. We traced transient anion binding sites, obtained evidence for how light energy is used in the pumping mechanism, and identified steric and electrostatic molecular gates ensuring unidirectional transport. An interaction with the π-electron system of the retinal supports transient chloride ion binding across a major bottleneck in the transport pathway. These results allow us to propose key mechanistic features enabling finely controlled chloride transport across the cell membrane in this light powered chloride ion pump. This work has been created in a collaboration between the SFB 1078 (C6 Schapiro and B3 Heberle), the ETH Zürich, and the PSI Villigen.

Feb 03, 2022

DFG project granted for AG Kozuch - Understanding Antibiotic Resistance and Enzymatic Catalysis by Combining Computational and Experimental Molecular Biophysics

As part of a DFG-third-party funded project, the Kozuch group will explore the relationship between the evolution of antibiotic resistance and the physical forces or non-covalent interactions that exist within enzymatic catalysts. Towards this goal, we will make use of a combined approach of computational and experimental vibrational spectroscopy in defined, external electric fields. Interested candidates for a doctoral thesis within this project to are invited to contact Dr. Jacek Kozuch ( jacek.kozuch@fu-berlin.de ).

Jan 03, 2022

Offener Hörsaal: Prof. Dr. Joachim Heberle - Vortrag "Verantwortung für die eigene Forschung"

Biophysiker und der Ombudsmann Prof. Dr. Joachim Heberle spricht bei einem öffentlichen Vortrag über die Verantwortung, die Wissenschaftlerinnen und Wissenschaftler für die eigene Forschung tragen. Hybrider Vortrag im Rahmen der Ringvorlesung "Offener Hörsaal: Ambivalenz der Wissenschaften – Nutzen und Schaden"

Nov 25, 2021

The Moderator

Focus on “Good Research Practice”: An Interview with Professor of Physics Joachim Heberle, Head of the Newly Established Office of the Central Ombudsperson at Freie Universität Berlin

Jul 02, 2021

Konfliktfrei Publizieren – Erfahrungen des „Ombudsman für die Wissenschaft“

Prof. Dr. Joachim Heberle, Mitglied im Ombudsgremium, und Dr. Hjördis Czesnick, Leiterin der Geschäftsstelle des Ombudsman für die Wissenschaft, berichten über typische Konflikte in natur- und lebenswissenschaftlichen Arbeitsgruppen, die im Zusammenhang mit der Publikation von Forschungsdaten aufkommen können. Im Vordergrund steht die Frage, wie Konflikte, z.B. auch Betreuungskonflikte, vermieden werden können.

May 20, 2021

How is a nerve impulse generated?

Biophysicists resolve structural rearrangements of a sodium pump at highest temporal and spatial resolution

Jan 05, 2021

For physicists affected by the war in Ukraine