Experimental Molecular Biophysics
Dr. Jacek Kozuch
Tel: +49 30 838 56163
Electrostatic Effects in Biological Processes
I aim at understanding how electrostatic interactions sculpt structural motifs in biological macromolecules and give rise to their unrivalled functionalities. In particular, I am interested in such structures found in enzymatic active sites, ion/proton channel pores as well as complex assemblies within biological membranes.
I explore this question with a particular focus on the mechanisms of evolution towards antimicrobial resistances, which present a major global health issue of today’s world. As such, I have studied the evolution of electrostatic catalysis in antibiotic resistance against β-lactam antibiotics previously. Now, I am extending this concept to the interplay between electrostatic and protonation effects, for instance, in the proton conductance through viral proton channels as part of the Collaborative Research Center 1078 (https://www.sfb1078.de/). Towards this goal I use a multidisciplinary experimental and theoretical approach centered around advanced vibrational spectroscopic approaches.