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AG Kozuch

Experimental Molecular Biophysics

Dr. Jacek Kozuch

Arnimallee 14
Raum 1.1.35
14195 Berlin
Germany
Tel: +49 30 838 56163

Research Focus

Electrostatic Effects in Biological Processes

I aim at understanding how electrostatic interactions sculpt structural motifs in biological macromolecules and give rise to their unrivalled functionalities. In particular, I am interested in such structures found in enzymatic active sites, ion/proton channel pores as well as complex assemblies within biological membranes.

I explore this question with a particular focus on the mechanisms of evolution towards antimicrobial resistances, which present a major global health issue of today’s world. As such, I have studied the evolution of electrostatic catalysis in antibiotic resistance against β-lactam antibiotics previously. Now, I am extending this concept to the interplay between electrostatic and protonation effects, for instance, in the proton conductance through viral proton channels as part of the Collaborative Research Center 1078 (https://www.sfb1078.de/). Towards this goal I use a multidisciplinary experimental and theoretical approach centered around advanced vibrational spectroscopic approaches.