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CRC/TRR 186 - Molecular Switches in the Spatio-Temporal Control of Cellular Signal Transmission (since 2016)

How does a distinct set of molecular switches control the spatio-temporal regulation of a diverse range of biological processes?

Biological signals are generated by molecular switches. These allow temporal and spatial coordination of a wide range of cellular processes. The overarching goal of our research consortium is to functionally analyze how a distinct set of molecular switches controls the spatio-temporal regulation of a diverse range of biological processes.

Intriguingly, in many cases, the molecular events that are downstream of the activation of a molecular switch trigger a cellular switch such as cell fate decisions between survival and apoptosis. To investigate the molecular mechanisms that link molecular switches to cellular switches in living cells, we use advanced chemical biology tools such as photoactivatable membrane lipids.

Coordinating university

University of Heidelberg

Vice-coordination

Freie Universität

Involved research group

Research Group Clementi

CRC/TRR 186

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